Excimer Laser Angioplasty System

Induction year:
Inducted individuals:
Dr. James Forrester
Dr. Tsvi Goldenberg
Dr. Warren Grundfest
Dr. James Laudenslager
Dr. Frank Litvack
Dr. Thomas Pacala
Inducted organizations:
Advanced Interventional Systems, Inc.
Cedars-Sinai Medical Center Spectronetrics
NASA Jet Propulsion Laboratory

Excimer Laser Angioplasty, utilizing a laser system initially developed for satellite-based atmospheric studies, is now a powerful instrument for treating heart disease. Excimer laser technology was initially pioneered at NASA’s Jet Propulsion Laboratory for remote sensing of the ozone layer. Other laser types are too hot for delicate coronary surgery and could damage tissue, cause blood vessel spasms, or create blood clots. The excimer is a `cool` laser that uses ultraviolet light energy to operate at 65° C, a temperature human tissue can tolerate.

Laser angioplasty is a procedure where a thin fiber-optic catheter is inserted into an artery in the leg and threaded to a blockage in a coronary artery. A tiny optical assembly diffuses the laser strand into a small cone-shaped laser beam as it is emitted from the catheter. The non-thermal laser vaporizes blockages in the artery without damaging delicate tissue. The procedure can be performed in a non-surgical setting using a local anesthetic. The hospital stay is minimal, and there is less post-operative pain, discomfort, and risk to the patient. Developed by Advanced Interventional Systems, Inc., the Dymer 200+ excimer laser angioplasty system vaporizes the buildup of fatty deposits – called plaque – in the arteries. It is safer than coronary bypass operations and offers wider utility than balloon angioplasty. In clinical trials the success rate in opening blocked coronary arteries was shown to be 85 percent, with fewer complications than in balloon angioplasty. In January 1992, the system received Food and Drug Administration approval for treatment of coronary disease.